EXERCÍCIO DE VIBRAÇÃO DE CORPO INTEIRO E INFLAMAÇÃO SISTÊMICA DE BAIXO GRAU EM IDOSOS: UMA REVISÃO NARRATIVA

Abstract

Population aging is associated with alterations in the immune system that favor the development of a chronic low-grade inflammatory state known as inflammaging, characterized by increased levels of pro-inflammatory mediators such as interleukin-6 (IL-6) and an imbalance with anti-inflammatory cytokines such as interleukin-10 (IL-10). In this context, non-pharmacological interventions capable of modulating systemic inflammation have been widely investigated. Whole-body vibration exercise (WBV) has emerged as an alternative characterized by low physical effort and metabolic demand, with potential applicability in older populations. The aim of this narrative review was to critically synthesize the available evidence regarding the effects of WBV on systemic low-grade inflammatory markers in older adults, with a specific focus on IL-6 and IL-10. A literature search was conducted in PubMed, Web of Science, Scopus, and EMBASE, resulting in five eligible studies, including clinical trials and experimental studies employing both acute and chronic WBV protocols. Overall, the findings indicate a lack of consistent changes in IL-6 and IL-10 concentrations following the intervention, regardless of participants’ clinical profile or the duration of the WBV protocols. However, some evidence suggests modulation of inflammatory pathways at the cellular level, such as reduced expression of Toll-like receptors (TLR-2 and TLR-4), indicating potential immunomodulatory effects not captured by circulating biomarkers. In conclusion, WBV does not appear to consistently alter IL-6 and IL-10 levels but may act on underlying inflammatory mechanisms. Future studies should prioritize protocol standardization and the assessment of inflammatory kinetics to better understand the impact of WBV on low-grade inflammation in aging.

Keywords: Cytokines; Exercise; Systemic inflammation; Older adults; Biomarkers.